Events in MathSys and Complexity Science
This is a calendar page detailing events within the MathSys CDT. It also acts as a booking diary for the Seminar Room D1.07. To book D1.07 please email Sheetal.Sharma@warwick.ac.uk
Please note that your event booking is for D1.07 only. The adjacent common room is a private area for the MathSys Centre that cannot used as part of your booking.
MathSys CDT events have priority for D1.07 room bookings.
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Complexity Forum - Martin Weigt
Title: Inference of protein-protein interactions from multi-species sequence data using statistical-physics inspired approaches
Abstract:
Experimental approaches to transient protein interactions arelaborious and serendipitous, and our understanding of fundamentalquestions like the identification of interaction surfaces or thespecificity of molecular recognition between interacting proteins arefar from being solved. We propose a computational approach basedon recent techniques from the statistical physics of disordered systems,which exploits the natural sequence variability of homologous proteinsacross hundreds of species species. Using bacterial two-componentsignal transduction (TCS) as a test case, we show that our method isable (i) to identify inter-protein residue contacts and to facilitatethe prediction of protein complex strutures, and (ii) to reconstruct amolecular recognition code which elucidates specificity in signaltransduction in bacteria.
[M. Weigt, R.A. White, H. Szurmant, J.A. Hoch, T. Hwa, "Identificationof direct residue contacts in protein-protein interaction by messagepassing", Proc. Natl. Acad. Sci. 106, 67 (2009).]