Events in MathSys and Complexity Science
This is a calendar page detailing events within the MathSys CDT. It also acts as a booking diary for the Seminar Room D1.07. To book D1.07 please email Sheetal.Sharma@warwick.ac.uk
Please note that your event booking is for D1.07 only. The adjacent common room is a private area for the MathSys Centre that cannot used as part of your booking.
MathSys CDT events have priority for D1.07 room bookings.
Click here to see all seminars taking place in the Mathematics InstituteLink opens in a new window
Click here to see the calendar for SBIDERLink opens in a new window.
Complexity Forum- Peter Sadler
Title: Metal CompMetal Complexity in Biology and Medicinelexity in Biology and Medicine
Abstract:
There are 81 stable elements on earth. How does the human genome code for the elements which are essential for life? To a coordination chemist, the code for an essential metal is also a code for its ligands, for a metal complex (metal plus ligands). A metal complex can contain 2-10 ligands in various coordination geometries, with various thermodynamic binding strengths and ligand exchange rates (10-8 to 1010 s-1). Both essential and non-essential elements can be used in therapy, even radioactive ones. I will illustrate our attempts to control both the thermodynamic and kinetic properties of metal complexes and design novel anticancer agents. A major challenge for understanding the chemistry of life and for the discovery of new therapies for intractable diseases lies in unraveling the complexity of the chemistry of metals.
New trends for metal complexes with anticancer activity P.C.A. Bruijnincx and P.J. Sadler Current Opinion in Chemical Biology 2008, 12, 197-206