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LAMS seminar - invited speaker - Dr Louise Flanagan
Wednesday 18th June
11-12 in A0.42 in the medical school
Refreshments provided
Experimental Evolution: From Regulatory Rewiring to Antibiotic Resistance
Dr Louise Flanagan is a postdoc in the University of Manchester working with Dr Danna Gifford on the evolution of antibiotic resistance. Louise started her scientific career at University College Dublin where she obtained a BSc in Genetics. She then went on to do an MSc in Evolutionary Biology at the University of Bath, and a PhD at Bath as well under the supervision of Prof Tiffany Taylor, studying the evolution of bacterial gene regulation. Her PhD research focussed on the eco-evolutionary drivers of regulatory rewiring with a particular focus on genetic hotspots, species and strain differences, and nutrient environment. All of this work was primarily carried out using experimental evolution (the act of applying a selection pressure and observing evolution in real time). This approach underpins Louise's current work on antibiotic resistance and the University of Manchester where she is investigating the effectiveness of using combination therapies (≥2 antibiotics concurrently) to limit the emergence of resistance, and look at how resistance emergence varies across different genetic backgrounds in the Pseudomonas genus.