Nicola Rogers

Dr Nicola Rogers

Assistant Professor

Nicola.Rogers@warwick.ac.uk
+44 (0)2476 5 24456

About Me

I am interested in coordination chemistry for a range of biomedical applications.

Groups at 糖心TV

Scott Group

Affiliations

2017-2019 Elected member of the RSC Member Communities Board
MRSC
2017-date Editor of 鈥楥hemBAM鈥� Chemistry public engagement website (www.chembam.com)

Biography

2022-date Assistant Professor (lab manager for Prof Mike Ward), department of Chemistry, University of 糖心TV
2020 Winner - project (糖心TV press release)
2018-2022 SRF (with Prof Peter Scott), Department of Chemistry, University of 糖心TV
2017 Public Engagement with Research Officer, Department of Chemistry, University of Birmingham
2014-2016 PDRA (with Prof David Parker), Department of Chemistry, Durham University
2014 PDRA (with Prof Thomas Meersmann), Sir Peter Mansfield Imaging Centre, Nottingham University
2010-2014 PhD student ( Department of Chemistry, University of Birmingham)

Research interests

I am interested in coordination chemistry for a range of biomedical applications. We develop bioactive self-assembled chiral metal complexes as potential therapeutic agents, some of which exhibit antimicrobial and/or anticancer activity. We also design transition metal complexes as Parashift MRI probes, in pursuit of gadolinium-free diagnostics and molecular probes for MRI.

I also have experience of designing metal chelators for industrial applications in lubricant oils, and designing analytical experiments for industry to characterise colloidal carbon nanomaterials for battery applications.

Publications

Selected Publications

'Glycoconjugated Metallohelices have Improved Nuclear Delivery and Spooress Tumour Growth In Vivo', H. Song, S. J. Allison, V. Brabec,* H. E. Bridgewater, J. Kasparkova, H. Kostrhunova, V. Novohradsky, R. M. Phillips,* J. Pracharova, N. J. Rogers,* S. L. Shepherd, P. Scott*, Angew. Chem., 59, 14677-14685 (2020)
'Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds', H. Song, N. J. Rogers,* V. Brabec,* G. J. Clarkson, J. P. C. Coverdale, H. Kostrhunova, R. M. Phillips, M. Postings, S. L. Shepherd, P. Scott*, Chem. Commun., 56, 6392-6395 (2020)
'Optically pure metallohelices that accumulate in cell nuclei, condense/aggregate DNA, and inhibit activities of DNA processing enxymes', O. Hrabina, J. Malina, H. Kostrhunova, V. Novohradsky, J. Pracharova, N. J. Rogers, D. H. Simpson, P. Scott, V. Brabec,* Inorg. Chem., 59, (5), 3304-3311 (2020).
'Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification', H. Song, N. J. Rogers, S. J. Allison, V. Brabec, H. Bridgewater, H. Kostrhunova, L. Markva, R. M. Phillips, E. C. Pinder, S. L. Shepherd, L. S. Young, J. Zajac, and P. Scott, Chem. Sci., 10, 8547-8557 (2019).

'Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways', D. H. Simpson, A. Hapeshi, N. J. Rogers, V. Brabec, G. J. Clarkson, D. J. Fox, O. Hrabina, G. L. Kay, A. K. King, J. Malina, A. D. Millard, J. Moat, D. I. Roper, H. Soing, N. R. Waterfield, and P. Scott, Chem. Sci., 10, 9708-9720 (2019).
鈥�Tailoring iridium luminescence and gold nanoparticle size for imaging of microvascular blood flow鈥�, N. J. Rogers, H. C. Jeffery, S. Claire, D. J. Lewis, G. Zikeli, N. J. Hodges, S. Egginton, G. B. Nash, Z. Pikramenou, , Nanomedicine (Lond), 12, 2725-2740 (2017).
鈥�Simultaneous triple imaging with two PARASHIFT probes: encoding anatomical information, pH and temperature using magnetic resonance shift imaging鈥�,K-L. N. A. Finney, A. C. Harnden, N. J. Rogers, D. O鈥橦ogain, P. K. Senanayake, A. Blamire, D. Parker, Chem. Eur. J. 23, 7976-7989 (2017).
鈥�PARASHIFT Probes: Solution NMR and X-ray Structural Studies of Macrocyclic Ytterbium and Yttrium Complexes鈥�, K. Mason, N. J. Rogers, E. A. Suturina, I. Kuprov, J. A. Aguilar, A, S, Batsanov, D. S. Yufit, D. Parker, Inorg. Chem.56, 4028-4038 (2017).
鈥�Molecular hydrogen and catalytic combustion in the production of hyperpolarized 83Kr and 129Xe MRI contrast agents鈥�, N. J. Rogers, F. Hill-Casey, K. F. Stupic, J. S. Six, C. Lesbats, S. P. Rigby, J. Fraissard, G. E. Pavlovskaya, T. Meersmann, PNAS, 113, 3164-3168 (2016).
鈥�A new paramagnetically shifted imaging probe for MRI鈥�, P. K. Senanayake, N. J. Rogers, K.-L. N. A. Finney, P. Harvey, A. M. Funk, J. I. Wilson, D. O鈥橦ogain, R. Maxwell, D. Parker, A. M. Blamire, Magn. Reson. Med., 77, 1307-1317 (2017).
鈥�Another challenge to paramagnetic relaxation theory: a study of paramagnetic proton NMR relaxation in closely related series of pyridine-derivatized dysprosium complexes鈥�, N. J. Rogers, K.-L. N. A. Finney, P. K. Senanayake, D. Parker, Phys. Chem. Chem. Phys., 18, 4370-4375 (2016).
鈥�Critical analysis of the limitations of Bleaney鈥檚 theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes鈥�, A. M. Funk, K.-L. N.A. Finney, P. Harvey, A. M. Kenwright, E. R. Neil, N. J. Rogers, P. K.Senanayake, D. Parker, Chem. Sci., 6,1655 (2015).
'High coating of Ru(II) complexes on gold nanoparticles for single particle luminescence imaging in cells鈥�, N. J. Rogers, S. Claire, G. Zikeli, S. Farabi, R. Harris, N. J. Hodges, I. Styles, Z. Pikramenou, 鈥�, Chem. Commun., 50, 617 (2014).

Patents

N. J. Rogers and Z. Pikramenou, University of Birmingham, 鈥�Composition used to image cells, mark biomolecules, incorporate nanoparticles into cells and monitor flow of marked biomolecules, comprises nanoparticles of noble metal (e.g. boron) functionalized with metal complex and surfactant鈥�, Patent WO2013004989-A1, (2013).
Thomas Meersmann, Nicola (Rogers) Simpson, Galina Pavlovskaya, University of Nottingham, 'Production of Hyperpolarized Gas', Patent filed 2016, PCTGB2016052730, WO2017042544.

Review Articles

鈥�Electromagnetic susceptibility anisotropy and its importance for paramagnetic NMR and optical spectroscopy in lanthanide coodination chemistry鈥�, O. A. Blackburn, R. M. Edkins, S. Faulkner, A. M. Kenright, D. Parker, N. J. Rogers, S. Shuvaev, Dalton Trans.,45, 6782-6800 (2016).
鈥�Biological applications of nanomaterials鈥�, N. J. Rogers, D. J. Lewis, , Nanoscience: Volume 3, 3, 276-323 (2016).

Teaching and supervision

Nicola teaches the following courses:

-鈥楳olecular Structure and Covalent Bonding鈥� in the first year undergraduate module CH160

-鈥楳etals in Medicine鈥� in the third year undergraduate module CH3F8

Nicola also runs the third year extended third year laboratory experiment I3.

I am supervising the following PhD student with Peter Scott:

Miles Postings, 鈥榓ntimicrobial metallohelices鈥�

At the moment I am unable to accept any further applications, but if you get in touch I'll see if a member of my team might be able to help.