Publications

PhD Theses:

Dr. Parminder Kaur, January 7th, 2007 Statistical Methods for Interpretation of High Resolution Mass Spectra Dr. Kaur is currently a Research staff scientist at the Case Western Reserve University Center for Proteomics and Bioinformatics in Cleveland, Ohio.

Dr. Vera Ivleva, 2007 Direct Coupling of Thin Layer Chromatography with Vibrationally Cooled MALDI-MS for the Analysis of Glycolipids from Biological Samples Dr. Ivleva is currently a staff scientist for Waters in Millford, Massachusetts.

Dr. Raman Mathur, February 28th, 2008 A Cryogenic Low Noise Amplifier for Fourier Transform Mass Spectrometry Dr. Mathur is an instrumentation research engineer at Thermo-Fisher Scientific, in San Jose, California.

Dr. Jason Cournoyer, February 28th, 2008 Mechanism of Electron Capture Dissociation and The Applicaion to the Differentiation of Isoaspartic and Aspartic Acid Residues Dr. Cournoyer is a research scientist at Perkin Elmer in Waltham, Massachusetts.

Dr. Konstantine Aizikov, December, 2009 Novel Computationan and Instrumentation Methodologies for Biological Fourier-Transform Ion Cyclotron Resonance Mass Spectrometric (FTICRMS) Imaging Kostya Aizikov's Thesis Dr. Aizikov is currently a research scientist for Thermo-Fisher Scientific in Bremen, Germany.

Dr. Xiaojuan Li, June, 2010 Mechanism of Electron Capture Dissociation and the Application to Protein Deamidation Download. Dr. Li is currently a research Scientist for Merck in upstate New York.

Dr. Nadia Sargaeva, January 13th, 2012 Deamidation and Related Problems in Structural Analysis of Peptides and Proteins. Download. Dr. Sargaeva is currently on maternity leave in Boston, MA, USA.

Dr. Tzu-Yung (Terry) Lin, November 2012, Advanced Electronics for Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Download. Dr. Lin is currently a postdoctoral fellow at Pacific Northwest National Lab.

Dr. Huilin Li, December 12th, 2012. Studies of Protein Post-Translational Modifications using High Resolution Tandem Mass Spectrometry. Dr. Li is currently a postoctoral fellow with Prof. Joe Loo at UCLA.

Dr. Yulin Qi, June 2013, Advanced Methods in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Dr. Qi is currently a Postdoctoral Fellow working with Prof. Dietrich Volmer at Saarland University in Germany.

Dr. Pilar Perez-Hurtado, June, 2013. FTICRMS approqach to Monitor Asparagine Deamidation and its Isomeric Products in Collagen from Ancient Bones. Dr. Perez-Hurtado is currently a sales engineer for Advion.

Dr. Rebecca Wills, May, 2013. High Resolution Tandem Mass Spectrometry of Large Biomolecules. Dr. Wills is currently a research scientist working for Jaguar/Land Rover in Stratford.

Dr. Andrea Lopez-Clavijo, May, 2013. Tandem Mass Spectrometry of Non-Enzymatically Glycated Peptides and Proteins. Dr. Lopez-Clavijo is currently a postdoctoral Fellow at Birmingham University.

Dr. Juan Wei, August 2014, Advanced Applications of High Performance Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Dr. Wei is currently a postdoctoral fellow at Boston University School of Medicine in the group of Prof. Cheng Lin and Prof. Catherine Costello.

Dr. Christopher A. Wootton, Exploring biomolecules, metallodrugs, and their interactions via the use of UHR-FT-ICR Mass Spectrometry. Dr. Wootton is currently a postdoctoral fellow here at the Ion Cyclotron Resonance laboratory at the University of 糖心TV.

Dr. Federico Floris, Pushing the limits of two-dimensional mass spectrometry. Federico Floris Thesis

Papers:

If you can鈥檛 get the publication directly, please email and I鈥檒l forward the .pdf file to you.

Publications (reverse chronological order):

2017

143. Wootton, C. A.; Lam, P. Y.; Willetts, M.; van Agthoven, M.; Barrow, M.; Sadler, P. J.; O'Connor, P., Automatic Assignment of Metal-containing Peptides in Proteomic LC-MS and MS/MS Datasets. Analyst 2017, in press.
142. R眉ger, C. P.; Schwemer, T.; Sklorz, M.; O鈥機onnor, P. B.; Barrow, M. P.; Zimmermann, R., Comprehensive chemical comparison of fuel composition and aerosol particles emitted from a ship diesel engine by gas chromatography atmospheric pressure chemical ionisation ultra-high resolution mass spectrometry with improved data processing routines. European Journal of Mass Spectrometry 2017, 23 (1), 28-39.
141. Agthoven, M. A.; O'Connor, P. B., Two鈥恉imensional mass spectrometry in a linear ion trap, an in silico model. Rapid Commun. Mass Spectrom. 2017, 31 (8), 674-684.
140. Alessandro Del Grosso, L.-D. G., Cookson K. C. Chiu, Guy C. Clarkson, Peter B. O'Connor, Martin Wills, A Class of Strained Alkyne Derived from 2,2'-Dihydroxy-1,1'Biaryls; Synthesis and Copper-Free Cycloaddition with Azides. Organic and Biomolecular Chemistry 2017, in press.

2016

139. Floris, F.; Agthoven, M. A. v.; Chiron, L.; Soulby, A.; Wootton, C. A.; Barrow, M. P.; Delsuc, M.-A.; Rolando, C.; O'Connor, P. B., 2-Dimensional IRMPD/FTICR MS of Calmodulin: A Top-Down and Bottom-Up Approach. J Am Soc Mass Spectrom 2016, 27 (9), 1531-1538.
138. Wei, J., et al.,Amyloid Hydrogen Bonding Polymorphism Evaluated by 15N{17O}REAPDOR Solid-State NMR and Ultra-High Resolution FTICR-MS. Biochemistry 2016, 55, 2065.
137. Simon, H. J., et al.,Uncoiling collagen: a multidimensional mass spectrometry study. Analyst 2016, 141, 157.
136. Agthoven, M. A. v., et al.,Two-Dimensional Mass Spectrometry for Proteomics, a Comparative Study with Cytochrome c. Anal Chem 2016, 88, 4409.

2015

135. Wei, J.; O'Connor, P. B., Extensive fragmentation of pheophytin-a by infrared multiphoton dissociation tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2015, 29, 2411-2418.
134. Wootton, C. A., et al.,Binding of an organo-osmium(II) anticancer complex to guanine and cytosine on DNA revealed by electron-based dissociations in high resolution Top-Down FT-ICR mass spectrometry. Dalton Transactions 2015, 44, 3624.
133. Wei, J.; O'Connor, P. B.,Extensive fragmentation of pheophytin-a by infrared multiphoton dissociation tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2015, 29, 2411.
132. Wei, J.; Bristow, A. W. T.; O'Connor, P. B.,The Competitive Influence of Li+, Na+, K+, Ag+, and H+ on the Fragmentation of a PEGylated Polymeric Excipient. J Am Soc Mass Spectrom 2015, 26, 166.
131. van Agthoven, M. A., et al.,Differentiating Fragmentation Pathways of Cholesterol by Two-Dimensional Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. J Am Soc Mass Spectrom 2015, 26, 2105.
130. Soulby, A. J.; Heal, J. W.; Barrow, M. P.; Roemer, R. A.; O'Connor, P. B.,Does deamidation cause protein unfolding? A top-down tandem mass spectrometry study. Protein Science 2015, 24, 850.
129. Lopez-Clavijo, A. F., et al.,Glucosepane: investigating formation and structure in tendon collagen. International Journal of Experimental Pathology 2015, 96, A15.

2014

128. Cho, Y.; Qi, Y.; O'Connor, P. B.; Barrow, M. P.; Kim, S.,Application of Phase Correction to Improve the Interpretation of Crude Oil Spectra Obtained Using 7 T Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. J Am Soc Mass Spectrom 2014, 25, 154.
127. Li, H., et al.,Mass Spectrometric Strategies to Improve the Identification of Pt(II)-Modification Sites on Peptides and Proteins. J Am Soc Mass Spectrom 2014, 25, 1217.
126. Lopez-Clavijo, A. F., et al.,Study of an Unusual Advanced Glycation End-Product (AGE) Derived from Glyoxal Using Mass Spectrometry. J Am Soc Mass Spectrom 2014, 25, 673.
125. Lopez-Clavijo, A. F.; Duque-Daza, C. A.; O'Connor, P. B.,Tandem mass spectrometry for the study of glyoxal-derived advanced glycation end-products (AGEs) in peptides. Rapid Communications in Mass Spectrometry 2014, 28, 25.
124. Smith, D. F.; Kilgour, D. P. A.; Konijnenburg, M.; O'Connor, P. B.; Heeren, R. M. A.,Absorption Mode FTICR Mass Spectrometry Imaging. Anal Chem 2013, 85, 11180.
123. Wei, J.; Bristow, A.; McBride, E.; Kilgour, D.; O'Connor, P. B.,D-alpha-tocopheryl Polyethylene Glycol 1000 Succinate: A View from FTICR MS and Tandem MS. Anal Chem 2014, 86, 1567.
122. Wills, R. H., et al.,Insights into the Binding Sites of Organometallic Ruthenium Anticancer Compounds on Peptides Using Ultra-High Resolution Mass Spectrometry. J Am Soc Mass Spectrom 2014, 25, 662.
121. Wills, R. H.; O'Connor, P. B.,Structural Characterization of Actinomycin D Using Multiple Ion Isolation and Electron Induced Dissociation. J Am Soc Mass Spectrom 2014, 25, 186.

2013

120. Griffiths, M. T.; Campo, R. D.; O'Connor, P. B.; Barrow, M. P.,Throwing Light on Petroleum: Simulated Exposure of Crude Oil to Sunlight and Characterization Using Atmospheric Pressure Photoionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Anal Chem 2013, online.
119.Wei, J.; Li, H.; Barrow, M. P.; O'Connor, P. B.,Structural Characterization of Chlorophyll-a by High Resolution Tandem Mass Spectrometry. J Am Soc Mass Spectrom 2013, 24, 753.
118. Qi, Y.; Liu, Z.; Li, H.; Sadler, P. J.; O'Connor, P. B.,Mapping the protein-binding sites for novel iridium(III) anticancer complexes using electron capture dissociation. Rapid Communications in Mass Spectrometry 2013, 27, 2028.
117. Qi, Y., et al.,Absorption-Mode Fourier Transform Mass Spectrometry: The Effects of Apodization and Phasing on Modified Protein Spectra. J Am Soc Mass Spectrom 2013, 24, 828.
116. Kilgour, D. P. A.; Wills, R.; Qi, Y.; O'Connor, P. B.,Autophaser: An Algorithm for Automated Generation of Absorption Mode Spectra for FT-ICR MS. Anal Chem 2013, 85, 3903.
115. Kilgour, D. P. A.; Neal, M. J.; Soulby, A. J.; O'Connor, P. B.,Improved optimization of the Fourier transform ion cyclotron resonance mass spectrometry phase correction function using a genetic algorithm. Rapid Communications in Mass Spectrometry 2013, 27, 1977.

2012

114. Wills, R. H.; Tosin, M.; O'Connor, P. B.,Structural Characterization of Polyketides Using High Mass Accuracy Tandem Mass Spectrometry. Anal Chem 2012, 84, 8863.
113. Wills, R.; Habtemariam, A.; Sadler, P. J.; O'Connor, P. B.,Mapping the Binding Sites of Organometallic Ruthenium Anticancer Compounds on Peptides using FTICR Mass Spectrometry. J Am Soc Mass Spectrom 2012, , submitted.
112. Lin, T.-Y.; Green, R. J.; O'Connor, P. B. Transimpedance Amplifier, UK Patent WO2008103970. 30 March 2012 2012.
111. Lin, C.; O'Connor, P. B., Ion Activation and Mass Analysis in Protein Mass Spectrometry. In Protein and Peptide Mass Spectrometry in Drug Discovery, Gross, M. L.; Chen, G.; Pramanik, B. N., Eds. John Wiley & Sons, Inc: Hoboken, New Jerssey, 2012.
110. Li, X.; Yu, X.; Costello, C. E.; Lin, C.; O'Connor, P. B.,Top-Down Study of beta(2)-Microglobulin Deamidation. Anal Chem 2012, 84, 6150.
109. Leach, F. E., III, et al.,Analysis of phase dependent frequency shifts in simulated FTMS transients using the filter diagonalization method. International Journal of Mass Spectrometry 2012, 325, 19.
108. Lopez-Clavijo, A. F.; Barrow, M. P.; Kilgour, D.; Rabbani, N.; Thornalley, P. J.; O'Connor, P. B. 2-imino-imidazole, a glyoxal-derived advanced glycation end product (AGE) in peptides. Submitted to Analytical Chemistry. 2012.
107. Lopez-Clavijo, A. F.; Barrow, M. P.; Rabbani, N.; Thornalley, P. J.; O'Connor, P. B. Determination of types and binding sites of Advanced Glycation Endproducts for Substance P. Submitted to Analytical Chemistry. 2012.
106. S. Schildknecht, C. Karreman, A. Daiber, C. Zhao, J. Hamacher, D. Perlman, B. Jung, B. van der Loo, P. O'Connor, M. Leist, V. Ullrich, and M.M. Bachschmid. Autocatalytic Nitration of Prostaglandin Endoperoxide Synthase-2 by Nitrite Inhibits Prostanoid Formation in Rat Alveolar Macrophages. Antioxidants and redox signalling 2012, 17, 1392-1406 DOI: 10.1089/ars.2011.4485.
105. Huilin Li, Peter B. O'Connor. Electron Capture Dissociation of Disulfide, Sulfur-Selenium, and Diselenide Bound Peptides. J. Am. Soc. Mass Spectrom. 2012, DOI: 10.1007/s13361-012-0473-0.
104. Huilin Li, Stephen A. Wells, J. Emilio Jimenez-Roldan, Rudolf A. R枚mer, Yao Zhao, Peter J. Sadler, Peter B. O'Connor. Protein Flexibility is Key to Cisplatin Cross-linking in Calmodulin. Protein Sci. 2012, 21, 1269-1279.
103. Perez P., Lam P., Kilgour D., Bristow A., McBride E., O鈥機onnor P., Use of High Resolution Mass Spectrometry for the Analysis of Polymeric Excipients in Drug Formulations. Analytical Chemistry, 2012. Just Accepted.
102. Lin, T.-Y.; Green, R. J.; O'Connor, P. B. A Low Noise Single-Transistor Transimpedance Preamplifier for Fourier-Transform Mass Spectrometry Using a T Feedback Network. Review of Scientific Instruments. 2012, 83 (9), 094102. .
101. Lin, T.-Y.; Green, R. J.; O'Connor, P. B. Use of Optical Receiver Circuit Design Techniques in a Transimpedance Preamplifier for High Performance Mass Spectrometry, 14th International Conference on Transparent Optical Networks (ICTON), Coventry, UK, July 2-5, 2012. .
100. Kilgour, D. P. A.; Mackay, C. L.; Langridge-Smith, P. R. R.; O'Connor, P. B., Use of an artificial immune system derived method for the charge state assignment of small-molecule mass spectra. Analytical Chemistry 2012, 84 (17), 7436-7439.
99. Kilgour, D. P. A.; Mackay, C. L.; Langridge-Smith, P. R. R.; O'Connor, P. B., Appropriate degree of trust: deriving confidence metrics for automatic peak assignment in high-resolution mass spectrometry. Analytical Chemistry 2012, 84 (17), 7431-7435.
98. Qi, Y.; Witt, M.; Jertz, R.; Baykut, G.; Barrow, M. P.; Nikolaev, E. N.; O'Connor, P. B., Absorption-mode spectra on the dynamically harmonized Fourier transform ion cyclotron resonance cell. Rapid Communications in Mass Spectrometry 2012, 26 (17), 2021-2026.
97. Qi, Y.; Barrow, M. P.; Li, H.; Meier, J. E.; Van Orden, S. L.; Thompson, C. J.; O'Connor, P. B., Absorption-Mode: The Next Generation of Fourier Transform Mass Spectra. Analytical Chemistry 2012, 84 (6), 2923-2929.
96. Li, X.; Yu, X.; Costello, C. E.; Lin, C.; O'Connor, P. B., Top-Down Study of beta(2)-Microglobulin Deamidation. Analytical Chemistry 2012, 84 (14), 6150-6157.
95. Perez. P.; O'Connor, P. B., Deamidation of Collagen. Analytical Chemistry 2012, 84 (6), 3017-3025.
94. Perez P.; O鈥機onnor P. Differentiation of Isomeric Amino Acid Residues in Proteins and Peptides Using Mass Spectrometry. Mass Spectrometry Reviews. DOI 10.1002/mas.20357

2011

93. Sargaeva, N. P.; Goloborodko, A. A.; O'Connor, P. B.; Moskovets, E.; Gorshkov, M. V., Sequence-specific predictive chromatography to assist mass spectrometric analysis of asparagine deamidation and aspartate isomerization in peptides. Electrophoresis 2011, 32 (15), 1962-1969.
92. Qi, Y.; Barrow, M. P.; Van Orden, S. L.; Thompson, C. J.; Li, H.; Perez-Hurtado, P.; O'Connor, P. B., Variation of the Fourier Transform Mass Spectra Phase Function with Experimental Parameters. Analytical Chemistry 2011, 83 (22), 8477-8483.
91. Lin, T.-Y.; Green, R. J.; O'Connor, P. B., A gain and bandwidth enhanced transimpedance preamplifier for Fourier-transform ion cyclotron resonance mass spectrometry. Review of Scientific Instruments 2011, 82 (12), 124101. .
90. Li, H.; Lin, T.-Y.; Van Orden, S. L.; Zhao, Y.; Barrow, M. P.; Pizarro, A. M.; Qi, Y.; Sadler, P. J.; O'Connor, P. B., Use of Top-Down and Bottom-Up Fourier Transform Ion Resonance Mass Spectrometry for Mapping Calmodulin Modifiedl by Platinum Anticancer Drugs. Analytical Chemistry 2011, 83 (24), 9507-9515.
89. D. F. Smith, K. Aizikov, M. C. Duursma, F. Giskes, D.-J. Spaanderman, L. A. McDonnell, P. B. O'Connor, R. M. A. Heeren, An External Matrix-Assisted Laser Desorption Ionization Source for Flexible FT-ICR Mass Spectrometry Imaging with Internal Calibration on Adjacent Samples. J. Am. Soc. Mass Spectrom. 2011, 22. 130-137. .
88. N. P. Sargaeva, C. Lin, P. B. O'Connor, Differentiating N-Terminal Aspartic and Isoaspartic Acid Residues in Peptides. Anal. Chem. 2011, 83. 6675-6682 .
87. X. Li, Y. Huang, P. B. O'Connor, C. Lin, Structural Heterogeneity of Doubly-Charged Peptide b-Ions. J. Am. Soc. Mass Spectrom. 2011, 22. 245-254. .
86. H. Li, Y. Zhao, H. I. A. Phillips, Y. Qi, T.-Y. Lin, P. J. Sadler, P. B. O'Connor, Mass Spectrometry Evidence for Cisplatin As a Protein Cross-Linking Reagent. Anal. Chem. 2011, 83. 5369-5376. .
85. K. Aizikov, D. F. Smith, D. A. Chargin, S. Ivanov, T.-Y. Lin, R. M. A. Heeren, P. B. O'Connor, Vacuum compatible sample positioning device for matrix assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry imaging. Rev. Sci. Inst. 2011, 82. Link.
84. N. P. Sargaeva, C. Lin, P. B. O'Connor, Unusual Fragmentation of beta-Linked Peptides by ExD Tandem Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2011, 22. 480-491. Link.

2010

83. N. P. Sargaeva, A. A. Goloborodko, P. B. O鈥機onnor, E. Moskovets, M. V. Gorshkov, Sequence-specific predictive chromatography to assist mass spectrometric analysis of asparagine deamidation and aspartate isomerization in peptides. Electrophoresis 2010 submitted .
82. Qi, Y.; Thompson, C. J.; Van Orden, S. L.; O'Connor, P. B., Phase Correction of Fourier Transform Ion Cyclotron Resonance Mass Spectra Using MatLab. J. Am. Soc. Mass Spectrom. 2011, 22. 138-147. Link.
81. X. J. Li, C. Lin, P. B. O'Connor, Glutamine Deamidation: Differentiation of Glutamic Acid and gamma-Glutamic Acid in Peptides by Electron Capture Dissociation. Anal. Chem. 2010, 82. 3606-3615 .
80. X. J. Li, C. Lin, L. Han, C. E. Costello, P. B. O'Connor, Charge Remote Fragmentation in Electron Capture and Electron Transfer Dissociation. J. Am. Soc. Mass Spectrom. 2010, 21. 646-656 .
79. X. Li, C. Lin, P. B. O'Connor, Cyclized B-ions observed using ECD. J. Am. Soc. Mass Spectrom. 2010. manuscript in preparation Link.
78. X. Li, C. Lin, L. Han, C. E. Costello, P. B. O'Connor, Charge Remote Fragmentation in Electron Capture and Electron Transfer Dissociation. J. Am. Soc. Mass Spectrom. 2010, 21. 646-656 .
77. X. Li, C. Lin, W. Cui, P. B. O'Connor, Top-Down Analysis of Deamidation products in Proteins. Anal. Chem. 2010. manuscript in preparation.
76. W. Y. K. Chan, T. W. D. Chan, P. B. O'Connor, Electron Transfer Dissociation with Supplemental Activation to Differentiate Aspartic and Isoaspartic Residues in Doubly Charged Peptide Cations. J. Am. Soc. Mass Spectrom. 2010, 21. 1012-1015 .

2009

75. R. Yamin, C. Zhao, P. B. O'Connor, A. C. McKee, C. R. Abraham, Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide. Molecular Neurodegeneration 2009, 4. .
74. I. Van Rhijn, D. C. Young, A. De Jong, J. Vazquez, T. Y. Cheng, R. Talekar, D. C. Barral, L. Leon, M. B. Brenner, J. T. Katz, R. Riese, R. M. Ruprecht, P. B. O'Connor, C. E. Costello, S. A. Porcelli, V. Briken, D. B. Moody, CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids (vol 206, pg 1409, 2009). J. Exp. Med. 2009, 206. 1831-1831 .
73. I. Van Rhijn, D. C. Young, A. De Jong, J. Vazquez, T. Y. Cheng, R. Talekar, D. Barral, L. Leon, M. B. Brenner, J. T. Katz, R. Riese, R. M. Ruprecht, P. B. O'Connor, C. E. Costello, S. A. Porcelli, V. Briken, D. B. Moody, CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids. J. Exp. Med. 2009, 206. 1409-1422 .
72. N. P. Sargaeva, C. Lin, P. B. O'Connor, Identification of Aspartic and Isoaspartic Acid Residues in Amyloid beta Peptides, Including A beta 1-42, Using Electron-Ion Reactions. Anal. Chem. 2009, 81. 9778-9786 .
71. R. Mathur, P. B. O'Connor, Artifacts in Fourier transform mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23. 523-529 .
70. K. Aizikov, R. Mathur, P. B. O'Connor, The Spontaneous Loss of Coherence Catastrophe in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2009, 20. 247-256 .

2008

69. R. S. Zee, D. R. Pimentel, X. Hou, M. Zang, C. X. Yao, P. B. O'Connor, M. M. Bachschmid, R. A. Cohen, Sirtuin-1 Zinc Thiolate Center Is a Direct Molecular Target of Oxidants. Free Radic. Biol. Med. 2008, 45. S76-S76 .
68. D. Nichols, K. Lewis, J. Oriala, S. Mo, R. Ortenberg, P. B. O'Connor, C. Zhao, P. Vouros, T. Kaeberlein, S. S. Epstein, Short peptide induces an "uncultivable" microorganism to grow in vitro. Applied & Environmental Microbiology 2008. in press Epub May 30, 2008 Link.
67. R. Mathur, R. W. Knepper, P. B. O'Connor, A Low-Noise Broadband Cryogenic Preamplifier Operated in a High-Field Superconducting Magnet. Ieee Transactions on Applied Superconductivity 2008, 18. 1781-1789 .
66. Li, X.; Cournoyer, J. C.; Lin, C.; O鈥機onnor, P. B. The effect of fixed charge modifications on electron capture dissociation J. Am. Soc. Mass Spectrom. 2008, in press. Available online 28 June 2008.
65. Li, X.; Cournoyer, J. C.; Lin, C.; O鈥機onnor, P. B. Use of 18O labels to monitor deamidation during protein and peptide sample processing J. Am. Soc. Mass Spectrom. 2008, 19, 855-864.
64. Cournoyer, J. C.; Lin, C.; O鈥機onnor, P. B. Gas-phase structure dissimilarity of protonated isomeric peptides revealed by IR-activated DR-ECD J. Am. Soc. Mass Spectrom. 2008, in revision.
63. Lin, C.; Cournoyer, J. C.; O鈥機onnor, P. B. Probing the gas phase folding kinetics of peptide ions by IR-activated DR-ECD J. Am. Soc. Mass Spectrom. 2008, 19, 780-789.

2007

62. Xie, B.; Luo, X.; Zhao, C.; Priest, C. M.; Chan, S.-Y.; O鈥機onnor, P. B.; Kirschner, D. A.; Costello, C. E. Molecular characterization of myelin protein zero in xenopus laevis peripheral nerve: Equilibrium between non-covalently associated dimer and monomer Int. J. Mass Spectrom. Ion Processes 2007, 268, 304-315 .
61. Lin, C.; Mathur, R.; Aizikov, K.; O鈥機onnor, P. B. First signal on the cryogenic Fourier-transform ion cyclotron resonance mass spectrometer J. Am. Soc. Mass Spectrom. 2007, 18, 2090-2093 .
60. Mathur, R.; Knepper, R. W.; O鈥機onnor, P. B. A low-noise, wideband preamplifier for a Fourier-transform ion cyclotron resonance mass spectrometer J. Am. Soc. Mass Spectrom. 2007, 18, 2233-2241 .
59. Zhao, C.; Cournoyer, J.; Xie, B.; Zaia, J.; Costello, C. E.; O鈥機onnor, P. B. Structural analysis of milk oligosaccharides and N-linked branched glycans by electron detachment dissociation 2007, in revision.
58. Zhao, C.; Xie, B.; Chan, S.-Y.; Costello, C. E.; O鈥機onnor, P. B. Collisionally activated dissociation and electron capture dissociation provide complementary structural information for permethylated oligosaccharides J. Am. Soc. Mass Spectrom. 2007, 19, 138-150 .
57. Zhao, C.; O鈥機onnor, P. B. Removal of polyethylene glycols from protein samples using titanium dioxide Anal. Biochem. 2007, 365, 283-285 .
56. Cournoyer, J. J.; O鈥機onnor, P. B. Analysis of deamidation in proteins in Protein Mass Spectrometry; Whitelegge, J. P., Ed., 2008, Elsevier, Amsterdam.
55. O鈥機onnor, P. B. The development of Matrix-assisted laser desorption ion sources In Electrospray ionization mass spectrometry; Cole, R. B., Ed.; 2007 Wiley Interscience, San Francisco.
54. O鈥機onnor, P. B.; Hillenkamp, F. MALDI mass spectrometry insturmentation In MALDI-MS: a practical guide to instrumentation, methods and applications; Hillenkamp, F., Peter-Katalinic, J., Eds.; 2007, Wiley-VCH Verlag Weinheim, Germany.
53. Kaur, P.; O鈥機onnor, P. B. Quantitative determination of isotope ratios from experimental isotopic distributions Anal. Chem. 2007, 79, 1198-1204 .

2006

52. Mathur, R.; O鈥機onnor, P. B. Design and implementation of a high power RF oscillator on a printed circuit board for multipole ion guides Rev. Sci. Instrum. 2006, 77, 114101 .
51. Kaur, P.; O鈥機onnor, P. B. Comparison of charge state determination methods for high resolution mass spectra IEEE Int. Conf. on Granular Computing May 10, 2006, 550-553 .
50. Cournoyer, J. C.; Lin, C.; Bowman, M. J.; O鈥機onnor, P. B. Quantitating the relative abundance of isoaspartyl residues in deamidated proteins by electron capture dissociation J. Am. Soc. Mass Spectrom. 2007, 18, 48-56. .
49. Belyayev, M. A.; Cournoyer, J. J.; Lin, C.; O鈥機onnor, P. B. The effect of radical trap moieties on electron capture dissociation spectra of substance P J. Am. Soc. Mass Spectrom. 2006, 17, 1428-1436 .
48. Lin, C.; Cournoyer, J. J.; O鈥機onnor, P. B. Use of a double resonance electron capture dissociation experiment to probe fragment intermediate lifetimes J. Am. Soc. Mass Spectrom. 2006, 17, 1605-1615. .
47. Zhao, C.; Sethuraman, M.; Clavreul, N.; Kaur, P.; Cohen, R. A.; O鈥機onnor, P. B. A detailed map of oxidative post-translational modifications of human p21ras using Fourier transform mass spectrometry Anal. Chem. 2006, 78, 5134-5142. .
46. Aizikov, K.; O鈥機onnor, P. B. Use of the filter diagonalization method in the study of space charge related frequency modulation in FTMS J. Am. Soc. Mass Spectrom. 2006, 17, 836-843 .
45. O鈥機onnor, P. B.; Cournoyer, J. J.; Pitteri, S. J.; Chrisman, P. A.; McLuckey, S. A. Differentiation of aspartic and isoaspartic acids using electron transfer dissociation J. Am. Soc. Mass Spectrom. 2006, 17, 15-19 .

44. Perlman, D. H.; Berg, E. A.; O鈥機onnor, P. B.; Costello, C. E.; Hu, J. Reverse transcription-associated dephosphorylation of hepadnavirus nucleocapsids Proc. Nat. Acad. Sci. USA 2005, 102, 9020-9025 .
43. O鈥機onnor, P. B.; Lin, C.; Cournoyer, J. J.; Pittman, J. L.; Belyayev, M.; Budnik, B. A. Long-lived electron capture dissociation product ions experience radical migration via hydrogen abstraction J. Am. Soc. Mass Spectrom. 2006, 17, 576-585 .
42. Kaur, P.; O鈥機onnor, P. B. Algorithms for automatic interpretation of high resolution mass spectra J. Am. Soc. Mass Spectrom. 2006, 17, 459-468 .
41. Cournoyer, J. J.; Lin, C.; O鈥機onnor, P. B. Detecting deamidation products in proteins by electron capture dissociation Anal. Chem. 2006, 78, 1264-1271 ..
40. O鈥機onnor, P. B.; Pittman, J. L.; Thomson, B. A.; Budnik, B. A.; Cournoyer, J. C.; Jebanathirajah, J.; Lin, C.; Moyer, S.; Zhao, C. A new hybrid electrospray Fourier transform mass spectrometer: Design and performance characteristics Rapid Commun Mass Spectrom 2006, 20, 259-266. .

2005

39. Jebanathirajah, J. A.; Pittman, J. L.; Thomson, B. A.; Budnik, B. A.; Kaur, P.; Rape, M.; Kirschner, M.; Costello, C. E.; O鈥機onnor, P. B. Characterization of a new qQq-FTICR mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins J. Am. Soc. Mass Spectrom. 2005, 16, 1985-1999 .
38. Ivleva, V. B.; Sapp, L. M.; O鈥機onnor, P. B.; Costello, C. E. Ganglioside analysis by thin-layer chromatography matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry J. Am. Soc. Mass Spectrom. 2005, 16, 1552-1560 .
37. Cournoyer, J. J.; Pittman, J. L.; Ivleva, V. B.; Fallows, E.; Waskell, L.; Costello, C. E.; O鈥機onnor, P. B. Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation Protein Science 2005, 14, 452-463.
36. Pittman, J. L.; O鈥機onnor, P. B. A minimum thickness gate valve with integrated ion optics for mass spectrometry J. Am. Soc. Mass Spectrom. 2005, 16, 441-445 .

2004

35. Moody, D. B.; Young, D. C.; Cheng, T.-Y.; Rostat, J.-P.; Roura-mir, C.; O鈥機onnor, P. B.; Zajonc, D. M.; Walz, A.; Miller, M. J.; Levery, S. B.; Wilson, I. A.; Costello, C. E.; Brenner, M. B. T-cell activation by lipopeptide antigens Science 2004, 203, 527-531.

34. Kaur, P.; O鈥機onnor, P. B. Use of statistical methods for quantitative determination of the number of trapped ions Anal. Chem. 2003, 76, 2756-2762 .
33. Budnik, B. A.; Moyer, S. C.; Pittman, J. L.; Ivleva, V. B.; Sommer, U.; Costello, C. E.; O鈥機onnor, P. B. High pressure MALDI-FTMS: Implications for proteomics Int. J. Mass Spectrom. Ion Processes 2004, 234, 203-212.
32. Ivleva, V. B.; Elkin, Y. N.; Budnik, B. A.; Moyer, S. C.; O鈥機onnor, P. B.; Costello, C. E. Coupling thin layer chromatography with high pressure matrix assisted laser desorption/ionization Fourier transform mass spectrometry for the analysis of ganglioside mixtures Anal. Chem. 2004, 76, 6484-6491 .

2003 and before

31. O鈥機onnor, P. B.; Budnik, B. A.; Ivleva, V. B.; Kaur, P.; Moyer, S. C.; Pittman, J. L.; Costello, C. E. A High pressure matrix-assisted laser desorption Fourier-transform mass spectrometry ion source designed to accommodate large targets with diverse surfaces J Am Soc Mass Spectrom 2003, 15, 128-132.
30. Moyer, S. C.; Budnik, B. A.; Pittman, J. L.; Costello, C. E.; O鈥機onnor, P. B. Attomole peptide analysis by high-pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry Anal. Chem. 2003, 75, 6449-6454. .
29. Leymarie, N.; Costello, C. E.; O鈥機onnor, P. B. Electron capture dissociation initiates a free radical reaction cascade J. Am. Chem. Soc. 2002, 125, 8949-8958.
28. O鈥機onnor, P. B.; Costello, C. A.; Earle, W. E. A high voltage RF oscillator for driving multipole ion guides J. Am. Soc. Mass Spectrom. 2002, 13, 1370-1375. .
27. Leymarie, N.; Berg, E. A.; McComb, M. E.; O鈥機onnor, P. B.; Grogan, J.; Oppenheim, F. G.; Costello, C. E. Tandem Mass Spectrometry for Structural Characterization of Proline-Rich Proteins: Application to Salivary PRP-3 Anal. Chem. 2002, 74, 4124-4132. .
26. Hopkins, C. E.; O鈥機onnor P, B.; Allen, K. N.; Costello, C. E.; Tolan, D. R. Chemical-modification rescue assessed by mass spectrometry demonstrates that 纬-thia-lysine yields the same activity as lysine in aldolase Protein Sci 2002, 11, 1591-1599.
25. McClellan, J. E.; Costello, C. E.; O鈥機onnor, P. B.; Zaia, J. Influence of charge state on product ion mass spectra and the determination of 4s/6s sulfation sequence of chondroitin sulfate oligosaccharides Anal. Chem. 2002, 74, 3760-3771 .
24. O鈥機onnor, P. B. Considerations for the design of a Fourier-transform mass spectrometer in the 4.2K cold bore of a superconducting magnet Rapid Commun Mass Spectrom 2002, 16, 1160-1167.
23. Mirgorodskaya, E.; O鈥機onnor, P. B.; Costello, C. E. A general method for precalculation of parameters for sustained off resonance irradiation/collision-induced dissociation J. Am. Soc. Mass Spectrom. 2002, 13, 318-324 .
22. O鈥機onnor, P. B.; Mirgorodskaya, E.; Costello, C. E. High pressure matrix-assisted laser desorption/ionization Fourier-transform mass spectrometry for minimization of ganglioside fragmentation J. Am. Soc. Mass Spectrom. 2002, 13, 402-407 .
21. Lim, A.; Prokaeva, T.; McComb, M. E.; O鈥機onnor, P. B.; Theberge, R.; Connors, L. H.; Skinner, M.; Costello, C. E. Characterization of transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping and DNA sequence analysis Anal. Chem. 2002, 74, 741-751 .
20. Costello, C. E.; Lim, A.; O鈥機onnor, P. B.; Prokaeva, T.; Connors, L. H.; Skinner, M. Identification of novel transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping Amyloid 2001, 8, 104-105.
19. O鈥機onnor, P. B.; Costello, C. E. A high pressure matrix-assisted laser desorption/ionization Fourier-transform mass spectrometry ion source for thermal stabilization of labile biomolecules Rapid Commun. Mass Spectrom. 2001, 15, 1862-1868.
18. van den Brink, O. F.; Boon, J. J.; O鈥機onnor, P. B.; Duursma, M. C.; Heeren, R. M. A. Matrix-assisted laser desorption/ionization Fourier transform mass spectrometric analysis of oxygenated triglycerides and phosphatidylcholines in egg tempera paint dosimeters used for environmental monitoring of museum display conditions J. Mass Spectrom. 2001, 36, 479-492.
17. O鈥機onnor, P. B.; Costello, C. E. Application of multishot acquisition in Fourier transform mass spectrometry Anal. Chem. 2000, 72, 5125-5130 .
16. O鈥機onnor, P. B.; Costello, C. E. Internal calibration on adjacent samples (INCAS) with Fourier-transform mass spectrometry Anal. Chem. 2000, 72, 5881-5885 .
15. O鈥機onnor, P. B.; Duursma, M. C.; Rooij, G. J. v.; Heeren, R. M. A.; Boon, J. J. Correction of time of flight shifted polymeric molecular weight distributions in MALDI-FTMS Anal. Chem. 1997, 69, 2751-2755 .
14. Guan, Z.; Kelleher, N. L.; O鈥機onnor, P. B.; Aaserud, D. J.; Little, D. P.; McLafferty, F. W. 193 nm photodissociation of larger multiply charged biomolecules Int. J. Mass Spectrom. Ion Processes 1996, 157/158, 357-364.
13. Moertz, E.; O鈥機onnor, P. B.; Roepstorff, P.; Kelleher, N. L.; Wood, T. D.; McLafferty, F. W.; Mann, M. Sequence tag identification of intact proteins by matching tandem mass spectral data against sequence databases Proc. Nat. Acad. Sci. USA 1996, 93, 8264-8267.
12. O鈥機onnor, P. B.; McLafferty, F. W. Oligomer characterizationof 4-22 kDa polymers by electrospray Fourier-transform mass spectrometry J. Am. Chem. Soc. 1995, 117, 12826-12831 .
11. O鈥機onnor, P. B.; Speir, J. P.; Wood, T. D.; Chorush, R. A.; Guan, Z.; McLafferty, F. W. Quadrupolar axialization of large multiply charged ions J. Mass Spectrom. 1996, 31, 555-559.
10. Aaserud, D. J.; Little, D. P.; O鈥機onnor, P. B.; McLafferty, F. W. Distinguishing N- and C- terminus ions for mass spectrometry sequencing of proteins without prior degradation Rapid Commun. Mass Spectrom. 1995, 9, 871-876.
9. Kelleher, N. L.; Senko, M. W.; Little, D. P.; O鈥機onnor, P. B.; McLafferty, F. W. Complete large-molecule high-resolution mass spectra from 50-femtomole microvolume injection J. Am. Soc. Mass Spectrom. 1995, 6, 220-221.
8. McLafferty, F. W.; Senko, M. W.; Little, D. P.; Wood, T. D.; O鈥機onnor, P. B.; Speir, J. P.; Chorush, R. A.; Kelleher, N. L. Electrospray ionization and Fourier-transfrom mass spectrometry in biomedical research Adv. Mass Spectrom. 1995, 13, 115-128.
7. O鈥機onnor, P. B.; Little, D. P.; McLafferty, F. W. Isotopic assignment in large molecule mass spectra by fragmentation of a selected isotopic peak Anal. Chem. 1996, 68, 542-545 .
6. O鈥機onnor, P. B.; McLafferty, F. W. High resolution ion isolation with the capacitively coupled open cell J. Am. Soc. Mass Spectrom. 1995, 6, 533-535.
5. O鈥機onnor, P. B.; Speir, J. P.; Senko, M. W.; Little, D. P.; McLafferty, F. W. Tandem mass spectrometry of carbonic anhydrase (29 kDa) J. Mass Spectrom. 1995, 30, 88-93.
4. Wood, T. D.; Chorush, R. A.; Wampler, F. M. I.; Little, D. P.; O鈥機onnor, P. B.; McLafferty, F. W. Gas phase folding and unfolding of cytochrome-c cations Proc. Nat. Acad. Sci. USA 1995, 92, 2451.
3. Little, D. P.; Speir, J. P.; Senko, M. W.; O鈥機onnor, P. B.; McLafferty, F. W. Infrared multiphoton dissociation of large multiply-charged ions for biomolecule sequencing Anal. Chem. 1994, 66, 2809-2815.
2. Marshall, P.; O鈥機onnor, P. B.; Chan, W.-T.; Kristof, P. B.; Goddard, J. D. In Gas Phase Metal Reactions; Fontijn, A., Ed.; Elsevier: Amsterdam, 1992.
1. Cioslowski, J.; O鈥機onnor, P. B.; Fleischmann, E. D. Is Superbenzene Superaromatic? J. Am. Chem. Soc. 1991, 113, 1086.

Patents:

1. O鈥機onnor, P. B. Apparatus and Method for Ion Cyclotron Resonance Mass Spectrometry USA 2003 10/338423