Bugg Group Publications

Nurika, D.C. Eastwood, T.D.H. Bugg, and G.C. Barker, J. Ind. Microbiol. Biotechnol., 47, 145-154 (2020).
T.D.H. Bugg, J.J. Williamson, G.M.M. Rashid, Curr. Opin. Chem. Biol., 55, 26-33 (2020).
R. Tramontina, J. Galman, S.R. Derrington, T.D.H. Bugg, N.J. Turner, F.M. Squina, N. Dixon, Green Chemistry, 22, 144-152 (2020).

2019

Z. Wei, R.C. Wilkinson, G.M.M. Rashid, D. Brown, V. F眉l枚p and T.D.H. Bugg, Biochemistry, 58, 5281-5293 (2019).
T.D.H. Bugg, R.V. Kerr, J. Antibiotics, 72, 865-876 (2019).
R. Rahmanpour, A. Ehibhatiomhan, Y. Huang, B. Ashley, G.M. Rashid, S. Mendel-Williams, and T.D.H. Bugg, Enz. Microb. Technol., 123, 21-29 (2019).

2018

R.S. Granja-Travez & T.D.H. Bugg, Arch. Biochem. Biophys. 660, 97-107 (2018).
鈥溾€� G.M.M. Rashid, X. Zhang, R.C. Wilkinson, V. F眉l枚p, B. Cottyn, S. Baumberger, and T.D.H. Bugg, ACS Chem. Biol., 13, 2920-2929 (2018).
G.F. Persinoti, D. Paixao, T.D.H. Bugg, and F.M. Squina, Genome Announcements, 6:e00353-18 (2018).
R.S. Granja-Travez, R.C. Wilkinson, G.F. Persinoti, F.M. Squina, V. F眉l枚p, and T.D.H. Bugg, FEBS Journal, 285, 1684-1700 (2018).
E.C. Moraes, T.M. Alvarez, G.F. Persinoti, G. Tomazetto, L.B. Brenelli, D.A.A. Paix茫o, G.C. Ematsu, J.A. Aricetti, C. Caldana, N. Dixon, T.D.H. Bugg, F.M. Squina, Biotechnology for Biofuels, 11:75 (2018)
Rommel Santiago Granja鈥怲ravez, Rachael C. Wilkinson, Gabriela Felix Persinoti, Fabio M. Squina, Vilmos F眉l枚p, Timothy D. H. Bugg, FEBS, [doi: 10.1111/febs.14437] (2018)

2017

R. Millar, R. Rahmanpour, E.W.J. Yuan, C. White, and T.D. Bugg, Biotechnology and Applied Biochemistry, [doi: 10.1002/bab.1536], (2017)
R. Rahmanpour, L.D.W. King & T.D.H. Bugg, Biochem. Biophys. Res. Commun.. 482, 57-61, [doi 10.1016/j.bbrc.2016.10.144], (2017)
A.T. Tran, E.E. Watson, V. Pujari, T. Conroy, L.J. Dowman, A.M. Giltrap, A. Pang, W-R. Wong, R.G. Linington, J. Saunders, S.A. Charman, N.P. West, T.D.H. Bugg, J. Tod, C.G. Dowson, D.I. Roper, D.C. Crick, W.J. Britton, R.J. Payne, Nature Comm. 14414 [doi 10.1038/ncomms14414], (2017)
S.Z. Awan, J.O. Chandler, P.J. Harrison, M.J. Sergeant, T.D.H. Bugg and A.J. Thompson, Frontiers Plant Sci., 8, article 357, [doi 10.3389/fpls.2017.00357], (2017)

2016

T.D.H. Bugg, R. Rahmanpour, and G.M.M Rashid. Production of Biofuels and Chemicals from Lignin. Springer Singapore, 2016. 131-146.
T.D. Bugg, M.T. Rodolis, A. Mihalyi, and S. Jamshidi, Bioorganic & medicinal chemistry, [doi:10.1016/j.bmc.2016.03.018], (2016)
R. Rahmanpour, D. Rea, S. Jamshidi, V. F眉l枚p, and T.D. Bugg, Archives of biochemistry and biophysics 594, 54-60. (2016)
Y. Zhu, A.Z. Ksibe, H. Sch盲fer, C.A. Blindauer, T.D. Bugg and Y. Chen, FEBS J., [doi:10.1111/febs.13902] (2016)
" C.S. Lancefield, G.M. Rashid, F. Bouxin, A. Wasak, W.C. Tu, J.P. Hallett, S. Zein, J. Rodriguez, S.D. Jackson, N.J. Westwood, and T.D. Bugg, ACS Sustainable Chem. Eng., [doi: 10.1021/acssuschemeng.6b01855] (2016)

2015

S.M. Cragg, G.T. Beckham, N.C. Bruce, T.D.H. Bugg, D.L. Distel, P. DuPree, A. Etxabe Green, B.S. Goodell, J. Jellison, J. McGeehan, S.J. McQueen-Mason, K. Schnorr, P. Walton, J.E.M. Watts, and M. Zimmer, Curr. Opin. Chem. Biol., 29, 108-119 (2015)
G.M.M. Rashid, C.R. Taylor, Y. Liu, X. Zhang, D. Rea, V. F眉l枚p & T.D.H. Bugg, ACS Chem Biol., 10, 2286–2294 (2015).
T.D.H. Bugg, R. Rahmanpour., Curr. Opin. Chem. Biol., 29, 10-17 (2015).
P.J. Harrison, S. Newgas, F. Descombes, S.A. Shepherd, A.J. Thompson & T.D.H. Bugg, FEBS Journal., 282, 3986–4000 (2015).
Z. Mycroft, M. Gomis, P. Mines, P. Law & T.D.H. Bugg, Green Chem., 17, 4974-4979(2015).
鈥� R. Rahmanpour & T.D.H. Bugg, Arch. Biochem. Biophys., 574, 93-98 (2015).
鈥溾€� P.D. Sainsbury, Y. Mineyeva, Z. Mycroft, and T.D.H. Bugg, Bioorg. Chem., 60, 102-109 (2015).

2014

鈥溾€� A. Mihalyi, S. Jamshidi, J. Slikas, and T.D.H. Bugg, Bio-Org. Med. Chem., 22, 4566-4571 (2014).
鈥溾€� M.T. Rodolis, A. Mihalyi, C. Ducho, K. Eitel, B. Gust, R.J.M. Goss, and T.D.H. Bugg, Chem Commun., 50, 13023- 13025 (2014)
鈥溾€� A.P. Spork, M. B眉schleb, O. Ries, D. Wiegmann, S. Boettcher, A. Mihalyi, T.D.H. Bugg, and C. Ducho, Chem. Eur. J., 20, 15292-15297 (2014).
鈥溾€� D. Braddick, S. Sandhu, D.I. Roper, M.J. Chappell and T.D.H. Bugg, Microbiology, 160, 1628-1636 (2014).
鈥� T.D.H. Bugg, Chemistry & Biology, 21, 168-169 (2014).
鈥�" Y. Zhu, E. Jameson, M. Crosatti, H. Sch盲fer, K. Rajakumar, T.D.H. Bugg, and Y. Chen, Proc. Natl. Acad. Sci. USA, 111, 4268-4273 (2014).
鈥�" J.M. Van Norman, J. Zhang, C.I. Cazzonelli, B.J. Pogson, P.J. Harrison, T.D.H. Bugg, K.X. Chan, A.J. Thompson and P.N. Benfey, Proc. Natl. Acad. Sci. USA, 111, E1300-E1309 (2014).
鈥溾€� M.T. Rodolis, A. Mihalyi, A. O鈥橰eilly, J. Slikas, D.I. Roper, R.E.M. Hancock, and T.D.H. Bugg, ChemBioChem, 15, 1300-1308 (2014).
鈥溾€� M. J. Sergeant, P. J. Harrison, R. Jenkins, G. R. Moran, T. D. H. Bugg & A. J. Thompson, N. J. Chem, 37, 3461 (2013).

2013

. Harrison, P.J., Bugg, T.D.H. Arch Biochem Biophys. doi: 10.1016/j.abb.2013.10.005 (2013)
. Sainsbury, P. D., Hardiman, E. M., Ahmad, M., Otani, H., Seghezzi, N., Eltis, L. D., & Bugg, T. D. H. ACS Chemical Biology Volume 8, Issue 10, pages 2151–2156 (2013)
Rahman Rahmanpour, Timothy DH Bugg FEBS Journal Volume 280, Issue 9, pages 2097–2104 (2013)

2012

S. Sandhu, J. A. Schouten, J. Thompson, M. Davis and T.D.H. Bugg, Analyst, 137, 1130-1136 (2012).
C.R. Taylor, E.M. Hardiman, M. Ahmad, P. Sainsbury, P.R. Norris, T.D.H. Bugg, Journal of Applied Microbiology, 113, 521-30 (2012).

芦Back

2011

T.D.H. Bugg, D. Braddick, C.G. Dowson and D. I. Roper, Trends in Biotechnology, 29, 167-173 (2011).
T.D.H. Bugg, M. Ahmad, E.M. Hardiman and R. Singh, Current Opinion in Biotechnology, 22, 394-400 (2011)
M. Ahmad, J.N. Roberts, E.M. Hardiman, R. Singh, L.D. Eltis and T.D.H. Bugg, Biochemistry, 50, 5096–5107 (2011).
J. N. Roberts, R. Singh, J.C. Grigg, M.E.P. Murphy, T.D.H. Bugg, and L.D. Eltis, Biochemistry, 50, 5108–5119 (2011).
T.D.H. Bugg, M. Ahmad, E. M. Hardiman and R. Rahmanpour. Natural Products Report, (2011), 28 (12), 1883 - 1896
J.G Hattersley, J. P茅rez-Vel谩zquez, M.J. Chappell, D. Bearup, D. Roper, C. Dowson, T.D.H. Bugg, N.D. Evans, Comput Methods Programs Biomed., 104., 70-80 (2011).

2010

M. Xin and T.D.H. Bugg,ChemBioChem, 11, 272-276 (2010).
M. Winn, R.J.M. Goss, K. Kimura, T.D.H. Bugg, Natural Product Reports, 27, 279-304 (2010).
A.E. Trunkfield, S.S. Gurcha, G.S. Besra, and T.D.H. Bugg, Bio-Organic and Medicinal Chemistry, 18, 2651-2663 (2010).
M. Ahmad, C.R. Taylor, D. Pink, K. Burton, D. Eastwood, G.D. Bending and T.D.H. Bugg, Molecular Biosystems, 6, 815-821 (2010).
J.A. L贸pez-R谩ez, W. Kohlen, T. Charnikhova, P. Mulder, A. Undas, M.J. Sergeant, F. Verstappen, T.D.H. Bugg, A.J. Thompson, C. Ruyter-Spira, H. Bouwmeester, New Phytologist, 187, 343-354 (2010).

芦Back

2009

M. J. Sergeant, J-J. Li, C. Fox, N. Brookbank, D. Rea, T. D. H. Bugg, J. Biol. Chem. (2009), 284, 5257-5264.
M. Brivio, J. Schlosrich, M. Ahmad, C. Tolond and T. D. H. Bugg, Org. Biomol. Chem. (2009), 7, 1368-1373.
E. Cressina, A.J. Lloyd, G. De Pascale, B.J. Mok, S. Caddick, D.I. Roper, C.G. Dowson, and T.D.H. Bugg, Bio-Org. Med. Chem, 17, 3443-3455 (2009).
V. Vinatier, C.B. Blakey, D. Braddick, B.R.G. Johnson, S.D. Evans, and T.D.H. Bugg. Chem. Commun., 4037-4039 (2009).
T.D.H. Bugg, Structure, 17, 913-914 (2009).
C. Paradis-Bleau, A. Lloyd, F. Sanschagrin, H. Maaroufi, T. Clarke, A. Blewett, C.G. Dowson, D.I. Roper, T.D.H. Bugg, and R.C. Levesque, Biochem. J., 421, 263-272 (2009).

芦Back

2008

G. De Pascale, A. J. Lloyd, J. A. Schouten, A. M. Gilbey, D. I. Roper, C. G. Dowson & T. D. H. Bugg, Journal of Biological Chemistry (2008), 283, 34571-34579.
D. Rea, R. Hovington, J. F. Rakus, J. A. Gerlt, V. Fulop, T. D. H. Bugg, D. I. Roper, Biochemistry (2008), 47(38), 9955-9965.
M. Xin, T. D. H. Bugg, Journal of the American Chemical Society (2008), 130(31), 10422-10430.
W.-H. Lam, K. Rychli, T. D. H. Bugg, Organic & Biomolecular Chemistry (2008), 6(11), 1912-1917.
T. D. H. Bugg, S. Ramaswamy, Current Opinion in Chemical Biology (2008), 12(2), 134-40.
J.-L. Mainardi, R. Villet, T. D. H. Bugg, C. Mayer, M. Arthur, FEMS Microbiology Reviews (2008), 32(2), 386-408.
A. Bouhss, A. E. Trunkfield, T. D. H. Bugg, D. Mengin-Lecreulx, FEMS Microbiology Reviews (2008), 32(2), 208-233.
A. J. Lloyd, A. M. Gilbey, A. M. Blewett, G. De Pascale, A. El Zoeiby, R. C. Levesque, A. C. Catherwood, A. Tomasz, T. D. H, Bugg, D. I. Roper, C. G. Dowson, Journal of Biological Chemistry (2008), 283(10), 6402-6417.
X.-H. Xu, A. E. Trunkfield, T. D. H. Bugg, F.-L. Qing, Organic & Biomolecular Chemistry (2008), 6(1), 157-161.
C. Li, M. Hassler, T. D. H. Bugg, ChemBioChem (2008), 9(1), 71-76.
C. E. Dodd, B. R. G. Johnson, L. J. C. Jeuken, T. D. H. Bugg, R. J. Bushby, S. D. Evans, Biointerphases (2008), 3(2), FA59-FA67.

芦Back

2007

D. Rea, V. Fueloep, T. D. H. Bugg, D. I. Roper, Journal of Molecular Biology (2007), 373(4), 866-876.
E. Cressina, A. J. Lloyd, G. De Pascale, D. I. Roper, C. Dowson, T. D. H. Bugg, Bioorganic & Medicinal Chemistry Letters (2007), 17(16), 4654-4656.
J.–J. Li, T. D. H. Bugg, Organic & Biomolecular Chemistry(2007), 5(3), 507-513.

芦Back

2006

Directed evolution of a non-heme-iron-dependent extradiol catechol dioxygenase: identification of mutants with intradiol oxidative cleavage activity. J. Schlosrich, K. L. Eley, P. J. Crowley, T. D. H. Bugg, ChemBioChem (2006), 7(12), 1899-1908.
Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing D-cysteine at position 4 or 5. J. A. Schouten, S. Bagga, A. J. Lloyd, G. de Pascale, C. G. Dowson, D. I. Roper, T. D. H. Bugg, Molecular BioSystems (2006), 2(10), 484-491.
Catalytic role for arginine 188 in the C-C hydrolase catalytic mechanism for Escherichia coli MhpC and Burkholderia xenovorans LB400 BphD. C. Li, J.-J. Li, M. G. Montgomery, S. P. Wood, T. D. H. Bugg, Biochemistry (2006), 45(41), 12470-12479.
Evidence for a gem-Diol Reaction Intermediate in Bacterial C-C Hydrolase Enzymes BphD and MhpC from 13C NMR Spectroscopy. J.-J. Li, C. Li, C. A. Blindauer, T. D. H. Bugg, Biochemistry (2006), 45(41), 12461-12469.
Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins. T. D. H. Bugg, A. J. Lloyd, D. I. Roper, Infectious Disorders: Drug Targets (2006), 6(2), 85-106.
Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme. C. Paradis-Bleau, M. Beaumont, L. Boudreault, A. Lloyd, F. Sanschagrin, T. D. H. Bugg, R. C. Levesque, Peptides (2006), 27(7), 1693-1700.
Antibiotic action and peptidoglycan formation on tethered lipid bilayer membranes. M. J. Spencelayh, Y. Cheng, R. J. Bushby, T. D. H. Bugg, J.-J. Li, P. J. F. Henderson, J. O'Reilly, S. D. Evans, Angewandte Chemie, (2006), 45(13), 2111-2116.
Arene cis-dihydrodiol formation: from biology to application. D. R. Boyd, T. D. H. Bugg, Organic & Biomolecular Chemistry (2006), 4(2), 181-192.
Interaction of the transmembrane domain of lysis protein E from bacteriophage phiX174 with bacterial translocase MraY and peptidyl-prolyl isomerase SlyD. S, Mendel, J. M. Holbourn, J. A. Schouten, T. D. H. Bugg Microbiology (2006), 152(10), 2959-67.

芦Back

2005

Expression, purification and preliminary crystallographic analysis of 2,4-dihydroxy-hepta-2-ene-1,7-dioate aldolase (HpcH) from Escherichia coliC. D. Rea, V. Fulop, T. D. H. Bugg, D. I. Roper, Acta Crystallographica, Section F: Structural Biology and Crystallization Communications (2005), F61(9), 821-824.
Lactone synthesis activity in a site-directed mutant of an extradiol catechol dioxygenase enzyme. S. Mendel, A. Arndt, T. D. H. Bugg, Chemical Communications (2005), (5), 666-668.
The Structure of the C-C Bond Hydrolase MhpC Provides Insights into its Catalytic Mechanism. G. Dunn, M. G. Montgomery, F. Mohammed, A. Coker,J. B. Cooper, T. Robertson, J.-L. Garcia, T. D. H. Bugg, S. P. Wood, Journal of Molecular Biology (2005), 346(1), 253-265.
Catalytic Mechanism of C-C Hydrolase MhpC from Escherichia coli: Kinetic Analysis of His263 and Ser110 Site-directed Mutants. C. Li, M. G. Montgomery, F. Mohammed, J.-J. Li, S. P. Wood, T. D. H. Bugg, Journal of Molecular Biology (2005), 346(1), 241-251.
Stereochemistry of the reaction catalysed by 2-hydroxy-6-keto-6-phenyl-hexa-2,4-dienoic acid 5,6-hydrolase (BphD). J.-J. Li, T. D. H. Bugg,Chemical Communications (2005), (1), 130-132.
Regulation and manipulation of the biosynthesis of abscisic acid, including the supply of xanthophyll precursors. I. B. Taylor, T. Sonneveld, T. D. H. Bugg, A. J. Thompson, Journal of Plant Growth Regulation (2005), 24(4), 253-273.

芦Back

2004

Synthetic 6-aryl-2-hydroxy-6-ketohexa-2,4-dienoic acid substrates for C-C hydrolase BphD: investigation of a general base catalytic mechanism.D. M. Speare, S. M. Fleming, M. N. Beckett, J.-J. Li, T. D. H, Bugg, Organic & Biomolecular Chemistry (2004), 2(20), 2942-2950.
Acid-Base Catalysis in the Extradiol Catechol Dioxygenase Reaction Mechanism: Site-Directed Mutagenesis of His-115 and His -179 in Escherichia coli 2,3-Dihydroxyphenylpropionate 1,2-Dioxygenase (MhpB). S. Mendel, A. Arndt, T. D. H. Bugg, Biochemistry (2004), 43(42), 13390-13396.
Diverse catalytic activities in the 伪尾-hydrolase family of enzymes: activation of H₂O, HCN, H₂O₂, and O₂. T. D. H. Bugg, Bioorganic Chemistry (2004), 32(5), 367-375.
Phospho-N-acetyl-muramyl-pentapeptide translocase from Escherichia coli: catalytic role of conserved aspartic acid residues. A. J. Lloyd, P. E. Brandish, A. M. Gilbey, T. D. H. Bugg, Journal of Bacteriology (2004), 186(6), 1747-1757.
Expression, purification, crystallization and preliminary characterization of uridine 5'-diphospho-N-acetylmuramoyl l-alanyl-d-glutamate:lysine ligase (MurE) from Streptococcus pneumoniae 110K/70. A. M. Blewett, A. J. Lloyd, A. Echalier, V. Fueloep, C. G. Dowson, T. D. H. Bugg, D. I. Roper,Acta Crystallographica, Section D: Biological Crystallography (2004), D60(2), 359-361.
A fluorescent analogue of UDP-N-acetylglucosamine: application for FRET assay of peptidoglycan translocase II (MurG). J.-J. Li, T. D. H. Bugg,Chemical Communications (2004), 2), 182-183.

芦Back

2003

Multivalent Conjugates of Poly-g -D-glutamic Acid from Bacillus licheniformis with Antibody F(ab') and Glycopeptide Ligands. E. J. Prodhomme, A. L. Tutt, M. J. Glennie, T. D. H. Bugg, Bioconjugate Chemistry (2003), 14(6), 1148-1155.
Dioxygenase enzymes: catalytic mechanisms and chemical models. T. D. H. Bugg, Tetrahedron (2003), 59(36), 7075-7101.
Synthesis and activity of 5'-Uridinyl dipeptide analogues mimicking the amino terminal peptide chain of nucleoside antibiotic mureidomycin A. N. I.Howard, T. D. H. Bugg, Bioorganic & Medicinal Chemistry (2003), 11(14), 3083-3099.
Stereochemical and mechanistic aspects of dioxygenase-catalyzed benzylic hydroxylation of indene and chroman substrates. D. R. Boyd, N. D. Sharma, N. I. Bowers, R. Boyle, J. S. Harrison, K. Lee, T. D. H. Bugg, D. T. Gibson, Organic & Biomolecular Chemistry (2003), 1(8), 1298-1307.
A density functional investigation of the extradiol cleavage mechanism in non-heme iron catechol dioxygenases. R. J. Deeth, T. D. H. Bugg, Journal of Biological Inorganic Chemistry (2003), 8(4), 409-418.
Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis. K.-I. Kimura, T. D. H. Bugg, Natural Product Reports (2003), 20(2), 252-273.

芦Back

2002

2-Hydroxy-6-keto-nona-2,4-diene 1,9-dioic acid 5,6-hydrolase: evidence from ¹⁸O isotope exchange for gem-diol intermediate. T. D. H. Bugg, S. M. Fleming, T. A. Robertson, G. J. Langley, Methods in Enzymology (2002), 354, 106-118.
Enzyme Assays, 2nd Edition Edited by R. Eisenthal and M. J. Hanson. T. D. H. Bugg, University of 糖心TV, UK. Natural Product Reports (2002), 19(5), 673.
Hammett analysis of a C-C hydrolase-catalysed reaction using synthetic 6-aryl-2-hydroxy-6-ketohexa-2,4-dienoic acid substrates. D. M. Speare, P. Olf, T. D. H. Bugg, Chemical Communications (2002), (20), 2304-2305.
Biological Properties of N-Acyl and N-Haloacetyl Neuraminic Acids: Processing by Enzymes of Sialic Acid Metabolism, and Interaction with Influenza Virus. A. J. Humphrey, C. Fremann, P. Critchley, Y. Malykh, R. Schauer, T. D. H. Bugg, Bioorganic & Medicinal Chemistry (2002), 10(10), 3175-3185.
Directed evolution of intradiol and extradiol catechol dioxygenases. K. Eley, T. D. H. Bugg, P. Crowley, Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, August 18-22, 2002 (2002), BIOL-043.
R. L. Harding, J. Henshaw, J. Tilling, T. D. H. Bugg, Journal of the Chemical Society, Perkin Transactions 1 (2002), (14), 1714-1722.

芦Back

2001

Extradiol Oxidative Cleavage of Catechols by Ferrous and Ferric Complexes of 1,4,7-Triazacyclononane: Insight into the Mechanism of the Extradiol Catechol Dioxygenases. G. Lin, G. Reid, T. D. H. Bugg, Journal of the American Chemical Society (2001), 123(21), 5030-5039.
Oxygenases: mechanisms and structural motifs for O₂ activation. T. D. H. Bugg, Current Opinion in Chemical Biology (2001), 5(5), 550-555.
Enhanced acid stability of a reduced nicotinamide adenine dinucleotide (NADH) analogue. P. H. Hentall, N. Flowers, T. D. H. Bugg, Chemical Communications (2001), (20), 2098-2099.
The development of mechanistic enzymology in the 20th century. T. D. H. Bugg, Natural Product Reports (2001), 18(5), 465-493.
Enzymes: Biochemistry, Biotechnology, Clinical Chemistry, by Trevor Palmer. T. D. H. Bugg, Natural Product Reports (2001), 18(4), 460.
Solving the riddle of the intradiol and extradiol catechol dioxygenases: how do enzymes control hydroperoxide rearrangements? T. D. H. Bugg, G. Lin, Chemical Communications (2001), (11), 941-952.
Solvolytic C-C Cleavage Reaction of 6-Acetoxycyclohexa-2,4-dienones: Mechanistic Implications for the Intradiol Catechol Dioxygenases. K. L.Eley, P. J. Crowley, T. D. H. Bugg, Journal of Organic Chemistry (2001), 66(6), 2091-2097.
Mechanistic studies of hydrolase enzymes on the aromatic degradation pathways of Escherichia coli. D. M. Speare, T. D. H. Bugg, Abstracts of Papers, 222nd ACS National Meeting, Chicago, IL, United States, August 26-30, 2001 (2001), BIOL-221.
Synthesis of novel inhibitors of phospho-N-acetylmuramylpentapeptide translocase (mraY). N. I. Howard, T. D. H. Bugg, Abstracts of Papers, 222nd ACS National Meeting, Chicago, IL, United States, August 26-30, 2001 (2001), BIOL-109.

芦Back

2000

Catalytic Mechanism of a C-C Hydrolase Enzyme: Evidence for a Gem-Diol Intermediate, Not an Acyl Enzyme. S. M. Fleming, T. A. Robertson, G. J. Langley, T. D. H. Bugg, Biochemistry (2000), 39(6), 1522-1531.
Enzymatic Breakdown of Poly-g-D-glutamic Acid in Bacillus licheniformis: Identification of a Polyglutamyl g -Hydrolase Enzyme. E. C. King, A. J. Blacker, T. D. H. Bugg, Biomacromolecules (2000), 1(1), 75-83.
Use of trityl thiol for stereoselective thioester synthesis: a new preparation of (S)-thiolactic acid. R. L. Harding, T. D. H. Bugg, Tetrahedron Letters(2000), 41(15), 2729-2731.
A biomimetic model reaction for the extradiol catechol dioxygenases. G. Lin, T. D. H. Bugg, G. Reid, Chemical Communications (2000), (13), 1119-1120.
Elucidation of the catalytic mechanisms of the non-haem iron-dependent catechol dioxygenases: synthesis of carba-analogues for hydroperoxide reaction intermediates. C. J. Winfield, Z. Al-Mahrizy, M. Gravestock, T. D. H. Bugg, Journal of the Chemical Society, Perkin Transactions 1 (2000), (19), 3277-3289.

芦Back

1999

Bacterial peptidoglycan biosynthesis and its inhibition. T. D. H. Bugg, Comprehensive Natural Products Chemistry (1999), 3 41-294
Structure-function studies on nucleoside antibiotic mureidomycin A: synthesis of 5'-functionalized uridine models. C. A. Gentle, S. A. Harrison, M. Inukai, T. D. H. Bugg, Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1999), (10), 1287-1294.
Role of the enamide linkage of nucleoside antibiotic mureidomycin A: synthesis and reactivity of enamide-containing analogues. C. A. Gentle, T. D. H. Bugg, Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1999), (10), 1279-1286.

芦Back

1998

Substrate selectivity and biochemical properties of 4-hydroxy-2-keto-pentanoic acid aldolase from Escherichia coli. J. R. Pollard, D. Rialland, T. D. H. Bugg, Applied and Environmental Microbiology (1998), 64(10), 4093-4094.
Enzymic cleavage of aromatic rings: mechanistic aspects of the catechol dioxygenases and later enzymes of bacterial oxidative cleavage pathways. T. D. H. Bugg, C. J. Winfield, Natural Product Reports (1998), 15(5), 513-530.
Covalent modification in aqueous solution of poly-g -D-glutamic acid from Bacillus licheniformis. E. C. King, W. J. Watkins, A. J. Blacker, T. D. H. Bugg, Journal of Polymer Science, Part A: Polymer Chemistry (1998), 36(12), 1995-1999.
Purification, characterization and reaction mechanism of monofunctional 2-hydroxypentadienoic acid hydratase from Escherichia coli. J. R. Pollard, T. D. H. Bugg, European Journal of Biochemistry (1998), 251(1/2), 98-106.
Aminoalkylphosphinate inhibitors of D-Ala-D-Ala adding enzyme. D. J. Miller, S. M. Hammond, D. Anderluzzi, T. D. H. Bugg, Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1998), (1), 131-142.

芦Back

1997

Pre-Steady-State Kinetic Analysis of 2-Hydroxy-6-keto-nona-2,4-diene-1,9-dioic Acid 5,6-Hydrolase: Kinetic Evidence for Enol/Keto Tautomerization. I. M. Henderson, T. D. H. Bugg, Biochemistry (1997), 36(40), 12252-12258.
Purification, Characterization, and Stereochemical Analysis of a C-C Hydrolase: 2-Hydroxy-6-keto-nona-2,4-diene-1,9-Dioic Acid 5,6-Hydrolase.W. W. Y. Lam, T. D. H. Bugg, Biochemistry (1997), 36(40), 12242-12251.
Chemical and biochemical properties of 2-hydroxypentadienoic acid, a homolog of enolpyruvic acid. J. R. Pollard, I. M. Henderson, T. D. H. Bugg,Chemical Communications (1997), (19), 1885-1886.
Exploring the catalytic mechanism of the extradiol catechol dioxygenases. T. D. H. Bugg, J. Sanvoisin, E. L. Spence, Biochemical Society Transactions(1997), 25(1), 81-85.
Regiospecific ester hydrolysis by orange peel esterase: an undergraduate experiment. T. D. H. Bugg, A. M. Lewin, E. R. Catlin, Journal of Chemical Education (1997), 74(1), 105-107.

芦Back

1996

Catechol dioxygenases from Escherichia coli (MhpB) and Alcaligenes eutrophus (MpcI): sequence analysis and biochemical properties of a third family of extradiol dioxygenases. E. L. Spence, M. Kawamukai, J. Sanvoisin, H. Braven, T. D. H. Bugg, Journal of Bacteriology (1996), 178(17), 5249-5256.
Cis-Trans Isomerization of a Cyclopropyl Radical Trap Catalyzed by Extradiol Catechol Dioxygenases: Evidence for a Semiquinone Intermediate.E. L. Spence, G. J. Langley, T. D. H. Bugg, Journal of the American Chemical Society (1996), 118(35), 8336-83
Modes of action of tunicamycin, liposidomycin B, and mureidomycin A: inhibition of phospho-N-acetylmuramyl-pentapeptide translocase fromEscherichia coli. P. E. Brandish, K.-I. Kimura, M. Inukai, R. Southgate, J. T. Lonsdale, T. D. H. Bugg, Antimicrobial Agents and Chemotherapy (1996), 40(7), 1640-1644.
Slow binding inhibition of phospho-N-acetylmuramyl-pentapeptide-translocase (Escherichia coli) by mureidomycin A. P. E. Brandish, M. K.Burnham, J. T. Lonsdale, R. Southgate, M. Inukai, T. D. H. Bugg, Journal of Biological Chemistry (1996), 271(13), 7609-14.

芦Back