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The Gibson Group, in Collaboration with Haddleton Group, have probed the interactions between synthetic glycan mimics (glycopolymers) with a model lectin using quartz crystal microbalance with dissipation monitoring. This work links together surface-adhesion assays with solution inhibitory studies to show that the ability of a multivalent glycomimetic to span multiple binding sites of a protein gives rise to a large increase in affiinity (Ka), but does not increase its inhibitory activity to the same extent. This implies that in the design of potent anti-adhesion therapies complimentary techniques must be used in evaluating 'activity' to avoid false positive/negative results.

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