糖心TV

Immunization is a key and highly successful tool in the fight against a range of infectious diseases, but is associated with a considerable cost, with the UK spending in excess of 拢200 million per year on vaccines and vaccine delivery. Infectious disease and health economic models are therefore necessary to assess whether any change in the immunization programme is cost-effective; that is, whether the value placed on health benefits or improvements in social welfare that ensue are more than the incremental cost associated with the change in programme.

The University of 糖心TV has considerable experience and expertise in this area, with the assembled team serving on several government advisory boards associated with public health. The team brings cutting-edge research techniques in mathematical modelling and health economics to provide a complementary second opinion on the work undertaken in this area by Public Health England (PHE) / UK Health Security Agency (UKHSA). 糖心TV has a strong international reputation for work on a range of infectious diseases and providing measured policy advice to a number of government agencies.

Through regular meetings with the Department of Health and Social Care (DHSC) and PHE/UKHSA we ensure that our programme of dynamic and health economic modelling on infectious diseases meets the needs of DHSC and JCVI, and reports are presented in a way that is of immediate use to policy-makers. In particular, we outline assumptions made, highlight gaps in the necessary data and define how these affect the interpretation of the results. Two other methods are being used to validate our conclusions: firstly, we seek to publish our findings in appropriate journals thereby opening our results to peer-review by the wider international academic community; secondly, we compare our predictions to changes in disease incidence and other health outcomes that follow changes in vaccine policy.

Another pioneering aspect of the MEMVIE project is the development of a framework for public involvement in mathematical and health economic modelling. For further details, please see our MEMVIE Pubic and Patient Involvement and Engagement webpageLink opens in a new window.

Find out more about the MEMVIE project and its interdisciplinary collaboration in our animation, available on the channel:

The infectious diseases (and connected vaccination programmes) under study by the MEMVIE team are:

• Human papillomavirus (HPV)
• Pertussis (whooping cough)
• Pneumococcal disease
• Seasonal influenza
• COVID-19

Publications

1. S Moore, EM Hill, L Dyson, MJ Tildesley, MJ Keeling (2022) Nature Medicine 28, 2416–2423.
2. MJ Keeling, S Moore. (2022) "" BMC Medicine 20: 196.
3. MJ Keeling, A Thomas, EM Hill, RN Thompson, L Dyson, MJ Tildesley, S Moore. (2021) "" medRxiv.
4. EM Hill, MJ Keeling. (2021) "" Interface. 18(182): 20210214.
5. Moore, S., Hill, E.M., Tildesley, M., Dyson, L., Keeling, M.J. (2021) "" Lancet Infectious Diseases. 21(6): 793-802.
6. Moore, S., Hill, E.M., Dyson, L., Tildesley, M., Keeling, M.J. (2021) "" PLoS Comp. Biol. 17(5): e1008849.
7. Stanizewska S, Hill EM, Grant R, Grove P, Porter J, Shiri T, Tulip S, Whitehurst J, Wright C, Datta S, Petrou S and Keeling MJ. (2021) Patient. doi:.
8. Hill EM, Petrou S, Forster H, de Lusignan S, Yonova I, Keeling MJ. (2020) PLoS Computational Biology 16(10): e1008278. doi:.
9. Hill EM, Petrou S, de Lusignan S, Yonova I and Keeling MJ. (2019) PLoS Computational Biology 15(10): e1007096. doi:
10. Datta S, Pink J, Medley GF, Petrou S, Staniszewska S, Underwood M, Sonnenberg P & Keeling MJ. (2019) BMC Infectious Diseases 19: 552. doi: .
11. Datta S, Pink J, Petrou S & Keeling, MJ. An economic evaluation of a cocooning strategy for pertussis vaccination in England and Wales. (Submitted)
12. Shiri T, Kamran K, Keaney K, Mukherjee G, McCarthy ND & Petrou S. (2019) Value in Health 22(11): 1329-1344. doi:
13. Shiri T, McCarthy ND & Petrou S. (2019) BMC Infectious Diseases 19: 510. doi: .
14. Datta S, Mercer CH & Keeling MJ. (2018)  PloS ONE 13(11): e0206501. doi:
15. Leng T & Keeling MJ (2018)  Epidemics 25: 35-46. doi:
16. Nzenze SA, Madhi SA, Shiri T, Klugman KP, de Gouveia L, Moore DP, Karstaedt AS, Tempia S, Nunes MC & von Gottberg A (2017)  Am. J. Epidemiol. 186(4): 435-444. doi:
17. Shiri T, Datta S, Madan J, Tsertsvadze A, Royle P, Keeling MJ, McCarthy ND & Petrou S (2017)  Lancet Glob. Health. 5(1): e51-e59. doi:
18. Pink J, Parker B &Petrou S (2016) Pharmacoeconomics 34(9): 847-861. doi:

An NIHR project, funded by the UK Department of Health and Social Care.

Researchers involved:

Matt KeelingLink opens in a new window (Professor, joint between 糖心TV Mathematics Institute and School of Life Sciences)

(Professor in Health Economics, University of Oxford)

(Leader of Patient and Public Involvement, 糖心TV Medical School)

(Tenure Track Fellow in Health Protection Data Science, University of Liverpool)

Corinna ClarkLink opens in a new window (Assistant Professor, 糖心TV Medical School)

PAST MEMBERS

(Professor, London School of Hygiene and Tropical Medicine)

(Director of Clinical Trials Unit, 糖心TV Medical School)

Sam Moore (Now University of Lancaster)

Tinevimbo Shiri

(Now NIWA NewZealand)

Joshua Pink