Dr Raphael Dias Teixeira

Supervisor Details

Contact Details

r.diasteixeira@bham.ac.uk

Scientific Background

Research Interests

My group works at the interface between structural biology and microbiology. We want to understand how bacteria survive, both when they are attacked by phages and when they stop growing and become tolerant to antibiotics. Much of our work follows nucleotides. NAD+ is destroyed by bacterial defence systems and exploited by phages, and its depletion pushes cells into dormancy through enzymes that cleave it. We are also interested in c-di-GMP, the signal that controls the switch between a motile lifestyle and life in a biofilm, and in how these signals are read by the proteins that bind them. We work mainly with Pseudomonas aeruginosa combining X-ray crystallography, cryo-EM and NMR with bacterial genetics, phage assays and live-cell imaging.

Supervision Style

In three words or phrases: Close support. Ideas welcome. Room to follow your own questions.

Provision of Training

The student will work directly alongside me at the bench, starting with microbiology and protein production before moving into structural work, so each method is learned at the right time. Learning will be supported by courses in structural biology and regular meetings to discuss the outcome of the experiments.

Progression Monitoring and Management

We will meet one to one every week to look at the data and agree what comes next, and the student will present to the group on a regular basis. At the start of each year we will write down what the project should achieve and revise it together when results send the work in a different direction.

Communication

My door is always open for questions. I sometimes send messages outside working hours because it suits my schedule, but I do not expect a reply on those times. I am open to talk about anything affecting your work, including things outside the lab.

Meetings

PhD Students can expect scheduled meetings with me at least once per fortnight. These meetings will be face-to-face and I am usually contactable for an instant response 3 or 4 days per week.

Work Patterns

Certain tasks in my lab need to occur at set times, and students need to be able to commit to a rota/timetable shared with other members of the team.

Notice Period for Feedback

I need at least 2 weeks' notice to provide feedback on written work of up to 5,000 words.

MIBTP Project Details

Primary supervisor for:

Project Title

See the PhD Opportunities section to see if this project is currently open for applications via MIBTP.

Please Note: The main page lists projects via BBSRC Research Theme(s) quoted and then relevant Topic(s).

Project Title

Secondary Supervisor(s):

University of Registration:

BBSRC Research Themes:

Sustainable Agriculture and Food (Animal Health and Welfare, Microbial Food Safety, Plant and Crop Science)
Renewable Resources and Clean Growth (Bio-energy, Industrial Biotechnology)
Understanding the Rules of Life (Immunology, Microbiology, Neuroscience and Behaviour, Plant Science, Soil Science, Stem Cells, Structural Biology, Systems Biology)
Integrated Understanding of Health (Ageing, Diet and Health, Pharmaceuticals, Regenerative Biology)

Project Outline

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Co-supervisor on a project / projects with

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Midlands Integrative Biosciences Training Partnership