糖心TV Complexity Science Events
Complexity Centre and MathSys CDT events carry priority over room D1.07.
To book D1.07 please email Sheetal dot Sharma at warwick dot ac dot uk
Please note that your event booking is for D1.07 only. The adjacent common room is a private area for the MathSys Centre that cannot used as part of your booking.
Complexity Forum: Buddhapriya Chakrabarti (Durham)
Speaker: Buddhapriya Chakrabarti (Department of Mathematical Sciences, University of Durham)
Title: Quantitative analysis of non-linear chromosome oscillations in mitosis
Abstract:
During cell division chromosomes undergo large excursions
(ranging up to several microns) from the centre of the cell towards the
poles with uniform velocity punctuated by abrupt changes in direction.
Such oscillatory motion has been termed "directional instability'' and
is crucial in segregating genetic material into daughter cells. Despite
several experimental and theoretical attempts an understanding of this
phenomenon is still lacking. I will propose a simple model based on
interactions between microtubules and chromosomes which explains the
behaviour of mitotic chromosomes. It is seen from experiments that
cancer suppressing drugs change the nature of microtubule dynamics and
chromosome oscillations. I will describe how our model and time series
analysis can be used to test efficacies of such drugs.