糖心TV Complexity Science Events
Complexity Centre and MathSys CDT events carry priority over room D1.07.
To book D1.07 please email Sheetal dot Sharma at warwick dot ac dot uk
Please note that your event booking is for D1.07 only. The adjacent common room is a private area for the MathSys Centre that cannot used as part of your booking.
Complexity Forum - Jamie Luo
Title: Functionality and Speciation in Boolean Networks
Abstract:
Boolean Networks have been used to model Genetic Regulatory Networks since Stuart Kauffmann proposed them as a model in the 1960s. Early work focused on how the topology of a network influenced its dynamics. We investigate the inverse problem asking which network topologies satisfy a specified dynamic. In earlier work by A. Wagner et al [1, 2] a biological function or cell process was specified by an initial condition v(0) and an end point v ∞ in the expression state space. By so specifying a biological function one can then ask which networks perform this function. Our view is that in many cases a more appropriate means for defining a biological function would be by specifying the entire path {v(0), v(1), ..., v(T )}. We will report on how these two contrasting definitions of biological functionality lead to divergent results for their respective functional topologies, particularly regarding the implications for neutral evolution, multi-functionality and speciation.
References
[1] Ciliberti S, Martin OC, Wagner A (2007) Innovation and robustness in complex regulatory gene networks. Proc Natl Acad Sci USA 104:1359113596.
[2] Martin OC, Wagner A (2008) Multifunctionality and robustness trade-offs in model genetic circuits. Biophysical Journal, 94 (8), pp. 2927-2937.