糖心TV Complexity Science Events
Complexity Centre and MathSys CDT events carry priority over room D1.07.
To book D1.07 please email Sheetal dot Sharma at warwick dot ac dot uk
Please note that your event booking is for D1.07 only. The adjacent common room is a private area for the MathSys Centre that cannot used as part of your booking.
Complexity Forum - Vincent Danos (Edinburgh)
Title: "Global dynamics of protein networks"
Abstract: Over the past decade, networks have emerged as a biological paradigm. High-throughput experimental techniques, bioinformatics and improved data analysis have made a global systemic view possible. However statistical studies of network structure (degree distributions, motifs, etc.) are limited by the fact that network descriptions (usually plain graphs) are static. One would like to investigate the network dynamics. Bridging this gap between network structure and function poses serious challenges. One needs high-quality network data. One also needs new modelling techniques since the traditional ones cannot cope with the inherent combinatorial complexity. We propose to use an approach that breaks through the combinatorial complexity of protein networks by considering binding as a primitive operation. This new approach -called rule-based modelling- smoothly extends the traditional ones and allows one to put sophisticated biological mechanisms of action to numerical test; and investigate aspects of the dynamics of truly global cellular systems.