糖心TV Complexity Science Events
Complexity Centre and MathSys CDT events carry priority over room D1.07.
To book D1.07 please email Sheetal dot Sharma at warwick dot ac dot uk
Please note that your event booking is for D1.07 only. The adjacent common room is a private area for the MathSys Centre that cannot used as part of your booking.
Complexity Forum- Peter Sadler
Title: Metal CompMetal Complexity in Biology and Medicinelexity in Biology and Medicine
Abstract:
There are 81 stable elements on earth. How does the human genome code for the elements which are essential for life? To a coordination chemist, the code for an essential metal is also a code for its ligands, for a metal complex (metal plus ligands). A metal complex can contain 2-10 ligands in various coordination geometries, with various thermodynamic binding strengths and ligand exchange rates (10-8 to 1010 s-1). Both essential and non-essential elements can be used in therapy, even radioactive ones. I will illustrate our attempts to control both the thermodynamic and kinetic properties of metal complexes and design novel anticancer agents. A major challenge for understanding the chemistry of life and for the discovery of new therapies for intractable diseases lies in unraveling the complexity of the chemistry of metals.
New trends for metal complexes with anticancer activity P.C.A. Bruijnincx and P.J. Sadler Current Opinion in Chemical Biology 2008, 12, 197-206